i'm simply saying that truth = empiric reality irrespective of the source.

over and over again, I keep hearing many "elites" complaining that they don't know what is and is not authentically human (because of AI). This is really almost irrelevant to humanity. Never do we care what is authentic or inauthentic if a computer program tells you something that is true and a human tells you something that is false which one is more important? the authentically human falsehood or the truth? truth is the pursuit and the medium which it's conveyed is irrelevant judge everything whether AI generated or human generated under the same standard

your colon cancer risk (and probabaly other cancer risks) are a product of your microbiome diversity https://aacrjournals.org/cancerres/article/86/7_Supplement/3993/779640/Abstract-3993-Artificial-intelligence-integrated. sticking with my thesis that we create cancer not through our genetic risk but from the environmental impact on our genetics. Colorectal cancer rates in adults under 50 have been rising about 3% per year High-fructose corn syrup and pesticides disrupt the gut microbiome When fructose (especially high high-fructose corn syrup intake) exceeds what the small intestine can absorb (roughly a daily soda’s worth), fructose spills into the colon Glyphosate and related agricultural chemicals act like low-dose antibiotics on gut bacteria. They preferentially knock out protective species (Lactobacillus, Bifidobacterium) while sparing pro-inflammatory ones, reducing production of butyrate and other short-chain fatty acids that normally protect the colon lining. Human genetics haven’t changed in 30 years, but the microbiome of someone born in 1990 has been marinating in fructose and pesticide residue since infancy in a way someone born in 1950 never was. If the microbiome is the mediator between modern exposures and tumor biology (as this study suggests) it helps explain why a cancer that used to belong to grandparents is now showing up in their grandchildren.

had openclaw with opus 4.7 create a book recommendation engine based on my prior likes and dislikes across 100 books. its first recommendation "red mars" by kim stanley robinson. so far excellent.

conversation with a friend today: Friend: Dude, have you heard of STRC!? Me: Yea Friend: It's incredible, as long as MSTR can sell their shares I can earn 11% Me: Why can they keep selling shares? Friend: Because they are backed by bitcoin. Me: So as long as bitcoin goes up long term you get 11% forever. Friend: Yeah! Me: So why not just buy bitcoin like Saylor? Friend: 🤔

most people afraid of raw milk are not afraid to eat parmigiano reggiano cheese

"Insulin resistance" is one of the most used terms in medicine and also one of the least precise When we say "insulin resistance," we're treating it like a single thing. Insulin does dozens of things in your body. In any given tissue, some insulin-signaling pathways can be impaired while others remain intact. In the liver: hyperinsulinemia drives lipogenesis (making fat) while simultaneously failing to suppress gluconeogenesis (making glucose). The same hormone in the same organ creates two dysfunctional outcomes. In skeletal muscle when fat builds up inside the muscle cells this then blocks the signal insulin uses to tell your muscles ", take in this sugar from the blood." This happens before liver dysfunction In your fat tissue, the problem is basically chronic, low-grade inflammation. When fat cells get overloaded, your immune system treats them almost like an injury and prevents insulin from appropriately releasing fat. Fat cells keep storing sugars as fat but slowly leak the fatty acids back out into the blood even when insulin is high. In the brain, when insulin reaches neurons, it helps tell your brain: "You've eaten you can stop feeling hungry now". The hypothalamus controls this and still gets the signal but can't pass it along properly due to PI3K signaling impairment. In all cases, insulin is the messenger molecule and still gets to its destination properly but all other mechanisms that originate from the insulin signal become dysfunctional. https://pubmed.ncbi.nlm.nih.gov/10903330/ https://pubmed.ncbi.nlm.nih.gov/24281010/ https://pubmed.ncbi.nlm.nih.gov/22385956/ Modern medicine only treats insulin resistance as a way to control blood sugar and ignore all the other organs which are affected due to their chronically inflamed and dysfunctional state.

ha! call me old-fashioned. I still prefer a human written text.

not sure the audiobook industry has much future. now i just have a llm powered voice system read me epubs.

https://www.weizmann.ac.il/immunology/elinav/sites/immunology.elinav/files/2022-06/Artificial%20sweeteners%20induce%20glucose%20intolerance%20by%20altering%20the%20gut%20microbiota.pdf Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 514(7521), 181–186 saccharin, sucralose, aspartame, and acesulfame-K disrupt the gut microbiome by reducing beneficial bacteria such as Lactobacillus and Bifidobacterium https://pmc.ncbi.nlm.nih.gov/articles/PMC11501561/ gut dysbiosis messes with production of short-chain fatty acids, which are critical for healthy lipid and glucose metabolism

point me to where i can read the papers on this