As to Payment Targets, probably not. Nosmero is intentionally opinionated, I've been trying to shape it around one premise: be a XMR ecosystem for creators and their supporters. Payment Targets' "render every rail and dispatch to external handlers" approach is not Nosmero's. Payment Targets, though, is awesome for general Nostr clients. As to I2P I looked at it when I got the itch to make something on a network that is even more decentralized that Nostr, but ended up trying out the Holepunch/Hyperswarm stack with Swarmnero at https://swarmnero.com It is kind of a port of Nosmero, complete with XMR tipping. I'm still poking around I2P to see if it can support an interesting project I'd want to work on.